Irina Sinakevitch
Arizona Research Laboratories
Division of Neurobiology
Tucson, AZ 85721
Telephone: (520) 621- 8383
Fax: (520) 621-8282
e-mail: isin@neurobio.arizona.edu,
Education
Research
experience
2000-present Postdoctoral research
associate, Arizona Research Laboratories Neurobiology Division, University
of Arizona
Advisor: Strausfeld N.J
2000,1999,1997,1995 Visiting
scientist Institute of Evolutionary Physiology and Biochemistry, Russia,
Russian Academy of Science, Laboratory of Invertebrate Neurophysiology, St.
Petersburg “Evolutionary approach in study of the nervous system morphology in
vertebrate and invertebrate”.
Advisors: Prof. Plotnikova S.I. and
Acad. Svidersky V.L.
1998-1999 Postdoctoral associate, SUNY
at Buffalo, USA, Dept. of Biochemical Pharmacology “Characterization ionic channels expressed in Xenopus oocyte.“
Advisor: Prof. Hall L.
1997 Postdoctoral research associate,
CNRS UPR 9023, Montpellier, France “Characterization of glutamate and glutamate
receptors in the nervous system of Drosophila fly”.
Advisors: Dr. Grau Y. and Dr. Bockaert
J.
1995-1996 Project coordinator of
the International Research Project: “The anti-idiotypic antibodies for biogenic
amine receptors.” supported by research grant INTAS-1994-1289 (Brussels)
University of Angers, Laboratory of Neurophysiology, Angers, France.
1991-1995 Doctoral student
University of Angers, Laboratory of Neurophysiology, Angers, France
“Neurosecretory functions of Dorsal Unpaired Median (DUM) neurons in the
terminal abdominal ganglion of
cockroach Periplaneta americana”.
Advisor: Prof. Pelhate M.
1987-1991 Master student, junior
research scientist, Institute of cytology of Academy of Sciences of the
USSR, Laboratory of Cytodiagnostics, Leningrad, “Cytofluorometric study of functions of
hepotocytes”.
Advisor:Prof. Kudryavtsev B.N.
“The physico-chemical properties of G-, F-, inactivated and
cleaved actin using AEDANS fluorescence attached to Cys 371”.
Advisors: Dr. Khatlina S.Y., Dr. Turoverov K.K.,
1986-1987 technician and Master student,
Central Research Institute of Roentgenology and Radiology, Ministry of Public
Health, Leningrad, “The study of the properties of cell membrane of Erlich
ascite carcinoma during the first hours after irradiation using the method of the fluorescence
spectroscopy.”
Advisor: Dr. Sungurov Y. A.
Grants,
Fellowships and Awards
1998-Fellowship of CAMBI (Cell and
Advanced Molecular Biology and Immunology)
1998-Philippe Foundation Inc. grant
1998-Women In Neuroscience Travel Award,
LA,
1997-Fellowship of Fondation pour la
Recherche Medicale (France)
1995-1996 - research grant
INTAS-1994-1289 (Brussels)
1991-1992 -
Fellowship from Conseil Général du Maine-et-Loire, Angers, France
1992-1995 -
Fellowship of Ministère des Affaires Etrangères, France (92-95)
1989-1990 - Fellowship of Academy of
Science of the USSR (1989-1990)
1992 December 5-9 Winter School of Functional
Anatomy. CNRS, Ile-de-France, Secteurs Paris A& B, Service de
la Formation, France.
1994 March 17-18 Proteins Engineering Recombinant
Bacteriophages: Applications to coliclonal antibodies. Atelier
de formation INSERM N 61. Le Vesinet, Paris, France.
1996 December 8-12 II Winter Course in Neurosciences
"Neural development: molecular and cellular mechanisms." Alicante,
Spain.
1997 September 22-4 Workshop on Principal of Neural
Integration, Instituto Juan March de Estudios e Investigaciones, Madrid, Spain.
1997 October 1-4 Autumn School in Cognitive
Neuroscience, University of Oxford, England
1997, December12-2 EMBO
course: “DNA Sequencing: Advanced Approaches, Automated Methods and Analysis”,
Heidelberg, Germany.
1998, July 1-7
“Synaptic Plasticity and Learning and Memory”, Berlin, Germany.
1998-1999 SUNY at Buffalo,
USA, Dept. of Biochemical Pharmacology
Training in electrophysiological techniques:
characterization ionic channels expressed in Xenopus oocyte by double microelectrode and patch clamp methods;
data analysis using computer programs; recording from larval muscle of Drosophila melanogaster; patch clamp of
embryonic culture of Drosophila
melanogaster.
Abstracts
Sinakevitch I., Strausfeld N.J. (2001)
Aspartate-like and glutamate-like immunoreactivity in insect optic lobes
reveals parallel visual pathways. Neuroscience abstr. 308.3
Niwa M., Sinakevitch I., Strausfeld N.J. (2001)
Homologous protocerebral regions in honey bee and cockroach brains revealed by
octopamine immunoreeactivity. Neuroscience abstr. 518.19
Farris
S., Sinakevitch I., Strausfeld N.J. (2001) Localization of glutamate,
aspartate, and marker for neuronal development in subsets of Kenyon cells in
the mushroom bodies of the cockroach nymph. Neuroscience abstr. 308.12.
Sinakevitch-Pean I., Zliu,
D. H. Allen, A.L. Goldin, L.M. Hall and K. Dong. (1998) Mutations affecting
interactions of the German cockroach Para channel with pyrethroids and sodium
channel site 2 neurotoxins. Neurosc. Abstr. II, 722.3:1821
Sinakevitch-Pean I., S.I.
Plotnikova, M. Geffard, J. Bockaert, Y. Grau. (1998) Glutamate-like
immunoreactivity in the adult brain of Drosophila
Melanogaster. E. J. of Neuroscience 10, suppl:285.
Sinakevitch-Pean I. (1997)
The functional organization of central nervous system of insects: comparison
with vertebrate. Principal of Neural Integration, Instituto Juan
March de Estudios e Investigaciones. 70 pp64-65
Publications
Sinakevitch
I., Farris S., Strausfeld N.J. (2001) Taurine-, aspartate- and glutamate-like
immunoreactivity identifies chemically distinct subdivisions of Kenyon cells in
the cockroach mushroom body. J. Comp. Neurol. 439:352-367
Plotnikova S.I.,
Sinakevitch-Pean I. (2001) Descending neurons of
supraesophageal ganglion of Dragonfly larvae Aeschna. J. of Evol.
Biochem. Physiol. V37(4):335-337 (In Russian).
Sinakevitch-Pean I., Geffard M, Plotnikova S.I.
(2001) Glutamate-like immunoreactivity in the central nervous system of Drosophila melanogaster. J.of Evol.
Biochem. Physiol. V37(1):64-68 (In Russian).
Amat C., Sinakevitch-Pean I., Hue B. (1997)
Proctolin-like immunoreactivity in spontaneous plateau action potential neurons
innervating the hindgut of the cockroach Periplaneta
americana. Neuroscience Research 29:263-268
Sinakevitch I., Geffard M., Pelhate M., Lapied B.
(1996) Anatomy and Targets of Dorsal Unpaires Median (DUM) neurones in the
terminal abdominal ganglion of the male cockroach Periplaneta americana L. J. Comp. Neurol.
367: 147-163.
Sinakevitch-Pean I.
(1995) Determination de la nature chimique du produit synthetise et libere par
les dorsal unpaired median (DUM) neurones et etude du role physiologique de ces
cellules neurosecretrices du 6ieme ganglion abdominal de la blatte Periplaneta americana L. Ph.D. Thesis
(In French).
Sinakevitch I G., Geffard M., Pelhate M., Lapied B.
(1995) Octopaminergic Dorsal Unpaired Median (DUM) neurones innervating the
colleterial glands of the female cockroach Periplaneta
americana. J. exp. Biol. 198:1539-1544.
Sinakevitch I.G., Geffard M., Pelhate M., Lapied B.
(1994) Octopamine-like immunoreactivity in the DUM cells innervating accessory
gland of male cockraoch Periplaneta
americana. Cell and Tissue Res., 276: 15-21.
Sinakevitch I.G., Coulon
J.F., Filmon R., Hue B. (1994) Relation entre innervation et activité
octopaminergique dans les glandes conglobées de la blatte mâle Periplaneta americana (L.). Arch. Intern. Physiol., Biochem. Biophys., 102: A115. (in French)
Dubreil V., Sinakevitch I.G., Hue B., Geffard M.
(1994) Neuritic GABAergic synapses in insect neurosecretory cells. Neuroscience
Research 19: 235-240.
Lapied B., Sinakevitch I., Grolleau F., Hue B.
(1994) DUM neurones in the cockroach TAG : morphological, electrophysiological
and pharmacological aspects. In : "Insect Neurochemistry and
Neurophysiology", Eds. Borkovec
A.B. and Loeb M.J., C.R.C. Press, Boca Raton, London Tokyo, pp. 101-104.
Lapied B., Tribut F., Sinakevitch I.G., Hue B.,
Beadle J. (1993) Neurite regeneration of long-term cultured adult insect
neurosecretory cells identified as DUM neurons. Tissue & Cell 25: 893-906
Okon (Zavadskaya) E.E., Sinakevich I.G., Kovaleva
Z.V., Bereskina E.V., Shavlovsky M.M., Iganatova T.N., Turoverov K.K.,
Kudryavtsev B.N. (1993) A cytophotometric study of the transferrin content in
the rat hepatocytes with monoclonal antibodies. Cytology, 35: 64-78. (In
Russian).
Khatlina S.Y., Collins J.H., Kuznetsova I. M.,
Sinakevich I.G., Turoverov K.K., Usmanova A.M. (1991) Physico-chemical
properties of actin cleaved with bacterial protease from E. Coli A2 strain.
FEBS. vol. 279: 49-51.
Sinakevich I.G., Bereskina E.V., Kovaleva Z.V.,
Zavadskaya E.E., Pleskach V.A., Ignatova I.N. (1990) Stamm of hybridoma MUSCULUS L. used for production
monoclonal antibodies to human transferrin. Patent of USSR 1759872 A1. (in
Russian)
Kovaleva Z.V., Sinakevich I.G., Zavadskaya E.E.,
Bereskina E.V., Pleskach V.A., Ignatova T.N. (1989) Preparation of hybridomas
producing monoclonal antibodies to human transferrin derived from the fusion of
murine splenocytes and murine myeloma cell sp EBR-5 line. Cytology (USSR), 31:
1106-1107. (in Russian)
Sungurov A.Y., Mumanzhinov V.V., Sinakevich I.G.,
Zhuikov A.G. (1989) Biophysical studies of surface of irradiated cells of
Ehrlich ascites carcinoma. Studia Biophysica, 129: 5-12.