Overview of Flybrain

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Flybrain contains neuroanatomical peer reviewed descriptions of the central and peripheral nervous system of Drosophila melanogaster . At the 'entry level' of the 'Atlas', the user will find a hypertext tour guide to the basic structure of the nervous system. Deeper levels will contain more specific information concerning different anatomical structures, developmental stages, and visualization techniques.

Toolbar: Clicking on the Flybrain logo returns the reader to the front page. The 'Status' button describes specific information for the current page. The 'Where am I?' button describes the current location in the Flybrain hierarchy. The 'Index' button takes the user to the Flybrain index. The 'Search' button takes the user to the Flybrain search engine, which allows searches on the basis of keywords and accession numbers. The 'Accession' button takes the user to a page which allows direct access on the basis of an accession number, or the compilation of many pages by giving a range or series of accession numbers.

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Schematic Representations: These provide diagrammatic views of the nervous system from a number of different perspectives. By clicking the cursor on a particular anatomical domain, the user will be connected to textual descriptions and images obtained by a range of different visualization techniques.

Silver Stain Atlas: The Atlas depicts serial sections of the Drosophila brain and thoracic/abdominal ganglia, displayed against a co-ordinate system and viewed from the front, top, and side (frontal, horizontal, saggital). Specific structures (tracts, neuropils, cell body groups) are labeled. Abbreviations are listed in the glossary of anatomical terms. Text descriptions provide movement to linked image files. For their own research needs, users may download images that are not annotated.

3D Project: The Flybrain 3D Project includes vrml models of the Drosophila brain and surrounding nervous system. Virtual dissections provide interactive guids to relationships amongst brain architectures.

Autofluorescence Atlas: This is organized and annotated in the same way as the Silver Stain Atlas, but is restricted to the adult brain.

Immunocytology: Antibody stained neuropils of Drosophila and related Diptera provide information about the chemical neuroanatomy of the central nervous system and are linked to relevant Atlas pages and Golgi images.

Golgi Impregnations: A library of representative impregnations is linked to the Atlases. Golgi impregnations provide examples of single neurons that pertain to the current Atlas page and provide details of neuronal architecture.

Enhancer-trap Images: Images of enhancer-trap lines display unique aspects of the nervous system that cannot be obtained using conventional methods. Entries are linked to appropriate Atlas pages and vice versa. Certain entries are linked to confocal stacks and, or to animations. Where the gene(s) corresponding to the site of insertion is known, there will be hypertext links to Flybase and to other relevant databases.

Distribution of Specific Gene Products: This section will include information on the distribution of identified/unidentified proteins relevant to neuronal function, and of neurotransmitters and neuromodulators. In situ hybridization data will also be included where informative.

Mutant phenotypes: Data on individual Drosophila genes are already available from FlyBase, to which links will be made where appropriate. Supplementary data, in particular images comparing wild-type and mutant anatomy will be provided in Flybrain.

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Page last modified: July 25, 2000 by Managers.